Abstract:
INTRODUCTION: The study was investigated to ameliorative effects of curcumin against E.coli infection induced hypothyroidism in mice. Female mice were E.coli induced intraperitoneal and mitochondrial-targeted curcumin (mt-c) give orally.
METHOD: The present investigation was conducted, Mitochondrial targeted curcumin synthesized by covalent linkage of curcumin with lipophilic cation. TPP (1.31 gm) reacted with HBr (350 ml) precursor to obtain lipophilicity. Reverse osmosis (RO) water 200 μl in (5×106) E.coli, and DMSO (2% v/v) were injected in mice by intraperitoneal, after three days 100 μl mt-c (0.12 mg/100 μl), RO water and DMSO were induced in mice for seven days. Control group mice for each experimental setup were given simultaneously RO water and DMSO.
RESULT: The thyroid gland weight of mice increased after bacterial toxicity and ameliorate with mt-C its weight decrease, the level of T3 and T4 decerase against bacterial toxicity and ameliorate with mt-C its level increased, Lipid peroxidation and Superoxide dismutase (SOD) increased the level against bacterial toxicity and ameliorate with mt-C its value decreased,where as level of GSH after toxicity decreased and ameliorate with mt-C its value increased.
CONCLUSION: The data suggest that effect of mt-c positive against E.coli toxicity on thyroid gland, which could be direct involvement of mt-c on the thyroid gland of mice.