Abstract:
Aim: Diabetic retinopathy is the most common preventable cause of blindness where early detection and treatment can be sight-saving. Search for biomarkers for the disease has been relentless. Traditional lipids have been used and we aim to determine whether new molecules; apolipoproteinA1 and B have stronger associations with diabetic retinopathy.
Methods: We performed a cross-sectional study and studied 117 patients. Serum lipid profile was assessed by autoanalyser. Serum apolipoproteinsA1 and B were measured using immunoturbidimetric kit, SGM ITALY, on autoanalyser. ApoB/A1 ratio was calculated. Retinopathy was graded from the digital retinal photographs, taken with Non Mydriatic Autofundus Camera AFC230/210, and classified according to International-Clinical-Diabetic-Retinopathy-Disease-Severity-Scale.
Results: Mean ApoA1 for mild, moderate, severe retinopathy, proliferative diabetic retinopathy (PDR) shows a significant negative correlation(p=0.001) with severity of retinopathy. Mean ApoB for mild, moderate, severe, PDR displayed significant positive correlation with severity of retinopathy(p=0.001). Mean ApoB/A1 for mild, moderate, severe, PDR showed highly significant positive correlation with severity of retinopathy(p<0.001). Similarly mean LDL for mild, moderate, severe, PDR showed insignificant association with severity of DR(p=0.081).
Conclusion: ApoA1 and ApoB are stronger biomarkers of diabetic retinopathy than traditional lipids and can thus facilitate early detection and treatment of the disease thus sparing sight for millions.