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December,2021 Issue

Abstract:

Phenytoin and carbamazepine are the most widely used antiepileptics. This case report is about rare idiosyncratic complication of long term use of phenytoin and carbamazepine induced myelosuppression in tertiary care hospital, Vijayapur, Karnataka. We report a case of an 18-year-old female patient, known case of seizure disorder for 6years for which she was on phenytoin and carbamazepine.  The patient presented with complaints of nasal bleeding and fever. Peripheral smear showing Pancytopenia (severe normocytic normochromic anemia with neutropenic leucopenia). Bone tissue biopsy report showed Hypo cellular marrow suggestive of Aplastic anemia. CT brain showing Leptomeningeal enhancement in parasagittal region of left parietal lobe – suggestive of focal meningitis the patient was treated with broad-spectrum antibiotics, antifungal, granulocyte colony stimulating factor, cyclosporine, and blood transfusion. Even after best efforts the patient’s condition worsened and collapsed. So the life-threatening complication like myelosuppression should be diagnosed early and appropriate management is the key in such complications. Reporting of such cases is necessary to create awareness among the clinicians.


2.A COMPARATIVE STUDY FOR PROGNOSIS OF ANOSMIA IN COVID-19

Dr. Vishal Gupta, Dr. Sujata Agarwal*, Dr. Govind Rankawat, Dr. Dileep Wadhwani, Dr. Lalit Wadhawan

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RAJASTHAN

Abstract:

Background: Anosmia is common in Coronavirus disease 2019, but its impact on prognosis is unknown. We aimed to analyze whether anosmia predicts in-hospital mortality or disease severity; and if patients with anosmia have a different clinical presentation or inflammatory response.
Methods: This retrospective observational case-control study included a total of 500 admitted patients of COVID-19 at SMS Medical College and attached hospital, Jaipur.190 patients had anosmia while 310 patients were without anosmia at the time of hospitalization. The patient’s data concerning demography, clinical profile, underlying medical illness, severity of disease, inflammatory markers, radiological imaging, and outcome were extracted from their medical records. All collected data were tabulated, compiled, analyzed and compared among both groups.
Results: Patients of both groups had matched demographic and underlying chronic medical illness. Patients with anosmia had higher prevalence (35.79%) of mild disease as compared to patients without anosmia (27.42%) with P = 0.0488. Similarly, proportion of severe disease was significantly lower in patients with anosmia (9.47%) as compared to patients without anosmia (27.42%) with P<0.01. COVID-19 related inflammatory markers especially neutrophil-lymphocyte ratio (NLR), CRP, D-dimer, ferritin and IL-6 were found to be significantly lower in patients with anosmia as compared to patients of without anosmia (P<0.05).The average CTSS was found to be lower in patients with anosmia (10.54 ± 4.24) as compared to patients without anosmia (15.61 ± 6.08) with P<0.01.Average duration of hospital stay was found to be 10.18 days in patients with anosmia and it was 15.62 days in patients without anosmia (P<0.01). Patients with anosmia had lesser mortality (0.53%) as compared to the patients without anosmia which had higher mortality (3.23%) with P=0.0455.
Conclusion: The presence of anosmia was an independent predictor of good outcome as reflected by a lower in-hospital mortality rate and lesser duration of hospital stay. In COVID-19 patients with anosmia had early hospitalization, less severe form of disease, least raised inflammatory markers, least lung involvement and least deterioration as compared to patients without anosmia.


Abstract:

In this paper we have studied the effect of adding zinc oxide (ZnO) in its micro size on the dielectric parameters of polyvinyl chloride (PVC), such as dielectric permittivity and dielectric loss factor, as they are very important parameters characterizing the dielectric materials. Using Broad Band Dielectric Spectrometer (BDS) in the frequency range (0.1Hz – 107 Hz), we have measured both dielectric constant (ɛ′) and dielectric loss (ɛ″) of PVC composites containing different contents of zinc oxide (5%, 7%, 9% and 11%) by weight of polymer. We have found that ɛ′ of PVC sample with (5%) ZnO is higher than that of Pure PVC one, and then a decrease in the dielectric constant (ɛ′) for the rest of concentrations is observed. Meanwhile, dielectric loss (ɛ″) increases over the frequency range for all composites comparing to pure PVC.


4.EXTENT OF DAMAGE AND LIFE LOSS DUE TO FLOODING IN THE LOWER GANDAK PLAIN

Dr. Ramashray Prasad* and Dr. Jitendra Rishideo

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NEW DELHI

Abstract:

Flood is a worldwide phenomenon causing loss of life, property, infrastructures and crop damage. In north Indian plain, it is very severe. It is caused by heavy torrential rain particularly in the Himalayan upper catchment in association with huge snow melt in higher altitudinal glaciers during summer when the temperature is high. Thus, precipitous slope, huge water availability and greater carrying capacity of flowing water produce enormous sediment load. When rivers debouch in the plain, slope is reduced drastically. It leads to reduction in water velocity, causing sediment to deposit. Rivers become much wide and later erosion become prominent. All these issues create serious condition for easy and safe passage of additional discharging water. Excess water is bound to spread in the surrounding areas. Therefore, flooding becomes inevitable and stagnating water in any area creates enormous difficulty to the people. Hence, flooding causes damage to crops, houses, roads, and telecommunications other infrastructures, and loss of life of people and their cattle. Apart from them, water-borne diseases are also spreading in the flood affected areas, causing suffering. With respect to the Lower Gandak Plain, these situations are very severe as huge mountainous catchment with small plain basin offers very unfavorable condition and the loss is very high. Hence, an attempt has been made in this article to (i) explain the extent of people affected and damage to crops and houses, (ii) through light the loss of life and cattle and (iii) deliberate on the loss of public utilities and their impact on the society in the Gandak Lower Plain. The analysis of this study will help in suggesting remedial measures to overcome the problems of flooding and its ill-effect.


5.PROXIMATE COMPOSITION AND NUTRITIONAL EVALUATION OF (CITRULLUS LANATUS) WATERMELON SEED FLOUR

*Adeleke, A. E., Onifade, A.P., Adegbite, A.A.,Isola O.E and Sangoremi, A.A.

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NIGERIA

Abstract:

This research work investigated the proximate, minerals and protein functional properties of Citrullus lanatus seed flour. The Proximate analysis was carried out using the method recommended by AOAC, 2000. The Atomic Absorption Spectroscopy (AAS) VG BULK 211 model was used to determine the mineral contents of the seed flour. The functional properties such as oil absorption capacity, water absorption capacity, bulk density, foam capacity and foam stability were determined using standard analytical methods. The proximate composition of C.lanatus seed flour for moisture, protein, crude fibre, fat, ash and carbohydrate were: 7.80, 37.36, 22.33, 23.00, 4.70 and 4.81% respectively. Protein has the highest percentage composition (37.36%) while the ash content has the least (4.70 %). The results of mineral composition showed that the seed flour contained in (mg/100g); Fe (125.55) Na (3.60) K (21.60), Ca (4.83), Mg (4.83), Zn (2.95) and Cu (57.20) respectively. The most abundant mineral in seed flour was Fe (125.55 mg/100g) and the least mineral was Zn (2.95 mg/100g). The study showed that the seed flour contained appreciable amount of essential minerals for body metabolism. The results for protein functional properties were: oil absorption capacities (21.50), water absorption capacity (8.66%), Bulk density (0.146 g/ml), foaming capacity (11.54%) and foaming stability (3.85%) respectively. This further suggested that seed flour has high nutritional values and may be used as food supplements for both domestic and industrial purposes.


Abstract:

Background: Human sexuality is a very complex behavior that is affected by many factors such as physiological, cognition and learning. The phenomenon of homosexuality is nothing new but homosexuals are still facing discrimination and stigma in our traditional taboos, they go through many problems like in getting jobs, getting and giving education, receiving health care services etc. Negative attitude regarding same sex attraction appears to be deeply ingrained in majority of the nurses’ mind as a socialization process. Lower sex knowledge was related to negative attitude towards gay/lesbian/bisexual behavior, masturbation, premarital sex and contraception.
Objective: To assess the knowledge and attitude regarding homosexuality among nursing students.
Methodology: Sample consisted of 200 nursing students from selected colleges of, Amritsar, Punjab. Convenient sampling technique was followed to select the sample. Knowledge of nursing students was assessed by Homosexuality Questionnaire and attitude was measured by Homosexuality attitude scale. The study was conducted in the month of January, 2013.
Results: Study findings revealed that 86.5% of students had average knowledge, 10% had good knowledge and merely 3.5% students had poor knowledge regarding homosexuality but on the other hand majority of study subjects (65.5%) had negative attitude towards homosexuality while remaining 34.5% had positive attitude. Karl Pearson’s coefficient of correlation was applied to find the correlation between knowledge and attitude which depicted weak positive correlation between knowledge and attitude (r=+0.204). ANOVA and ‘Z’ test were applied to assess the relationship of knowledge and attitude regarding homosexuality among nursing with socio demographic variables such as age, gender, religion, marital status, place of residence, current living area and source of information. While source of information showed significant relationship with both knowledge and attitude regarding homosexuality.